The Biological Efficiency of Gold Bauhinia variegata Nano-Extract and Its Impact On the Brains of Diabetic Rats

Abstract

The objective of this research was to reveal the biological efficacy of Bauhinia variegata extract incorporated with gold nanoparticles (Au-NPs) in preventing adverse effects on the brain of diabetic rats. Total antioxidant capacity level (TAC), peroxidation products concentration, acetylcholine esterase (ACHE) and β-amyloid (Aβ) levels, interleukin-1β (IL-1β) level and tumor necrosis factor-α
(TNF-α) level were assayed in brain tissues. Furthermore, different native protein and isoenzyme patterns. The findings of this study demonstrated that normal and diabetic rats received gold B. variegata nano-extract showed a significant decrease in TAC level with increasing peroxidation products concentration, ACHE and Aβ levels as well as elevation in the levels of TNF-α and IL-1β.
Native electrophoretic protein and isoenzyme patterns showed that administration of gold nanoextract caused physiological alterations. Compared to the similarity index (SI) in the brains of control rats, the severity of physiological alterations increased more in the diabetic group treated with nanoextract than in the diabetic and gold nano-extract treated groups. In conclusion, the native B.
variegata extract exhibited higher physiological ameliorative effect more than gold nano-extract against the deleterious effects induced in brains of diabetic rats.