Assessment of the Impact of Nutritional Status on the Prognosis of FMF Patients

Abstract

Background: Familial Mediterranean fever (FMF) is the most common monogenic autoinflammatory disease. A number of modifiers have been shown to influence inflammatory marker levels, as poor diet quality, being associated with elevated levels of circulating pro-inflammatory markers. Improved diet quality can beneficially affect inflammation. Objectives of study: Determine the effect of a set of
nutritional modifications on the clinical symptoms and biochemical parameters of patients with familial Mediterranean fever. This may provide evidence of the value of nutritional intervention in the amelioration of the symptoms of FMF patients and pave the way for the integration of Dietary counseling in the routine management of patients with familial Mediterranean fever. Patients and Methods: Quasi experimental study carried out among 90 patients with Familial Mediterranean fever during the period from August 2021 to August 2022. Patients received nutritional education for six months. After that, they were divided into two groups: Group A patients who adhere to nutritional instructions, and Group B patients who did not adhere to nutritional instructions. Comparison between
Group A and Group B was made, in terms of clinical symptoms and biochemical analyses, before receiving nutritional instructions and six months after receiving instructions. Results: Regarding clinical symptoms and biochemical analyses; In group A, there were statistically significant differences before the experiment and after the six-month. In group B, there were no statistically significant
differences indicating improved health status. Conclusion: Following a healthy diet combined with drug therapy leads to reducing the severity and frequency of clinical symptoms and improving biochemical results.