Effect of Mixture of Propolis and Albumin on Renal Hepatotoxicity by Lead (Pb) In Male Rats

Authors

  • Ryeaan Abd El Moneim Sayed Abd El Rahem Department of Home Economics, Faculty of Specific Education, Port-Said University, Port-Said, Egypt.
  • Amgad I. M. Khedr Department of Pharmacognosy, Faculty of Pharmacy, Port-Said University, Port-Said, Egypt.
  • Shaimaa H. Negm Department of Home Economics, Faculty of Specific Education, Port-Said University, Port-Said, Egypt.
  • Donia A. Mostafa Department of Home Economics, Faculty of Specific Education, Port-Said University, Port-Said, Egypt.

Keywords:

Lead Intoxication, Propolis, Albumin, Health, Rats, Immunity

Abstract

Lead is a natural occurring element that has a high atomic weight and is wide distributed in the environment, with a high degree of toxicity that affects health. This study investigated the effect of mixtures of propolis and albumin in renal hepatotoxicity by lead (Pb) in rats. Lead toxicity was evaluated in rats, after one dose of 0.5 ml(Pb) last 12 days. 25 male albino rats were used, average weight 180±10 grm, divided to 5 groups each of 5 mature rats, the first group control(g1) infected group with 0.5 ml lead(g2), group (3) fed a stable food +0.5 ml(Pb) +150mg/kg propolis+5mg albumin, group (4) fed stable food +0.5ml (Pb)+200mg/kg propolis + 5mg albumin, group (5) fed stable food +0.5ml (Pb)+300mg/kg propolis+5mg albumin Mixure treatment for 5 weeks. Blood picture, renal and liver
function, antioxidant, glutathione peroxidase, albumin and T-Testosterone were investigated. The obtained results confirm the values of the propolis and albumin mixtures as hematinic potentials, improve hepato-renal functions, elevate antioxidant and male hormone testosterone. It is concluded that propolis and albumin may improve health problems, confirm hematinic potential, hepato-renal function, immunity and male hormone production.

Published

20.12.2022