Optimization of Electro Spinning Parameters and Cytotoxicity Evaluation of Titanium Dioxide Nanofibers to be Used as a Biomaterial

Authors

  • Shaimaa Shaban Physics Department (Biophysics Branch), Faculty of Science, Al-Azhar (Girlsʼ Branch), Nasr City, Cairo, Egypt.
  • Aziza A. Elsaeid Physics Department (Biophysics Branch), Faculty of Science, Al-Azhar (Girlsʼ Branch), Nasr City, Cairo, Egypt.
  • Basma Ekram Polymer and Pigments Department, Chemical Industries Inst. National Research Centre, Dokki, Cairo, Egypt.
  • Areg E. Omar Physics Department (Biophysics Branch), Faculty of Science, Al-Azhar (Girlsʼ Branch), Nasr City, Cairo, Egypt.
  • Bothaina Abd El-Hady Polymer and Pigments Department, Chemical Industries Inst. National Research Centre, Dokki, Cairo, Egypt.

Keywords:

Polyvinyl pyrrolidone, titanium dioxide nanofibers, electro spinning, cytotoxicity

Abstract

The TiO2 nano fibers were prepared using the conventional sol gel method and the electro spinning technique. Also Polyvinyl pyrrolidone (PVP) polymer using a combination of sol-gel and electro spinning techniques. The effects of sol-gel and electro spinning on TiO2/PVP nanofibers diameter, in addition to polyvinyl pyrrolidone (PVP) concentration, needle Tip-to-collector distance and applied
voltage were evaluated. The optimum combination was determined to be a 10% PVP concentration, with the needle tip-to-collector distance 10 cm, and the applied voltage at 20 kV. The cytotoxicity of the prepared fibers was evaluated using fibroblasts and the results showed that, the fibers increased the cell viability of human normal fibroblasts (BJ1 cells), which indicates that, it can be safely used as a biomaterial.

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Published

05.11.2022

Issue

Vol. 12 No. 4 (2022): OCTOBER-DECEMBER 2022

Section

Articles

License

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.