Production and Application of Microbial Collagenase

Abstract

Enzymes known as collagenases are responsible for releasing collagen's peptide linkages. Nowadays, microbial collagenolytic proteases are receiving a lot of attention due to their better productivity and lower resource needs. The importance of proteases with collagenolytic activity stems from both their biological and industrial applications. They play a significant part in the recycling of collagenous waste on a global scale. Enzymes that break collagen's peptide bonds and trigger chemical reactions are called collagenases. Recent knowledge on collagen and collagenolytic proteases is provided in this review. In addition, the current study also discusses the most recent state of collagenases, including current methods and advanced technologies for microbial collagenases' separation, structure, production optimization, characterization, and applications.