Urinary Activin A Level as a Predictor of Nephropathy in Type 2 Diabetic Patients

Abstract

Background: Type 2 diabetes mellitus (T2DM) is a major health problem and its prevalence is increasing worldwide which results in high morbidity and mortality due to its wide spectrum of complications. Both diabetic nephropathy (DN) and diabetic retinopathy (DR) are serious microvascular complications and have been considered the major cause of blindness and end-stage renal failure. Objective: our study was conducted to assess the Urinary Activin A Level as a Predictor of Nephropathy in Type 2 Diabetic Patients Patients and methods: the study was conducted on 90 subjects 30 were healthy control and 60 had a diagnosis of T2DM according to American Diabetes Association Criteria (ADAC). Data were collected including, demographic, clinical, and laboratory data. Statistical analysis was carried out for all collected data using IBM SPSS. Statistical significance was determined at a p-value <0.05. Results: there was a significant increase between all studied groups with higher levels of urinary activin A in the macroalbuminuria group with a mean (252.14 ± 88.83). While, there was an insignificant difference between the control group and type 2 diabetic patients without albuminuria group as regard Activin A (p-value > 0.05). Conclusion: our current study suggests that urinary activin A is associated with the presence of DN so it can be used as a new marker for the prediction of DN as Activin A was positively correlated with the ACR in type 2 diabetic patients without albuminuria, type 2 diabetic patients with microalbuminuria, and type 2 diabetic patients with macroalbuminuria but there was no correlation between Activin A and ACR in normal control group.