Correlation Between Urinary Orosomucoid1 Level and Albumin to Creatinine Ratio in Type 2 Diabetic Patients

Abstract

Background: Orosomucoid 1, also known as alpha-1-acid glycoprotein is an acute-phase serum protein produced by the liver in response to inflammation and infection, plays an important role as an anti-inflammatory and immunomodulatory agent. The aim of this work was to evaluate the relation between urinary orosomucoid 1(UROM1) and albumin to creatinine ratio (ACR) in type 2 diabetes
mellites (T2DM). Methods: This cross-sectional study was carried out on 90 patients with T2DM. Patients were categorized into two equal groups: Group I: T2DM patients with normal ACR (less than 30 mg/g). Group II: T2DM with increased ACR (>30 mg/g). Results: UROM1 was significantly increased in patients with renal impairment (ACR >30mg/dl) than those without (ACR < 30mg/dl). UROM1 was positively correlated with diabetes duration, fasting, postprandial blood glucose, haemoglobin A1C, urea, creatinine, TGs, cholesterol, and low-density lipoproteins, while negatively correlated with estimated glomerular filtration rate, albumin, and high-density lipoproteins. UROM1 for early detection of diabetic nephropathy, at cut off value 7.995 with 96.42% sensitivity and 91.11% specificity. Conclusions: UROM1 could be used as a biomarker for early detection of diabetic nephropathy in T2DM.