Efficacy of Ginkgo biloba Leaves against Cisplatin Induced Nephrotoxicity in Rats
Keywords:kidney Functions, Nephrotoxicity, Ginkgo biloba Leaves, Cisplatin, Rats
Nephrotoxicity is one of the most common kidney problems and occurs when the body is exposed to a drug or toxin. The present work aimed to investigate the effect of Ginkgo biloba leaves on some minerals utilization in nephrotoxic induced rats. Forty adult male Sprague-Dawley rats (average body weight was 170±10 g) were divided randomly into eight groups as follow: group 1: negative control, was fed on basal diet. Groups 2, 3 and 4 were received Ginkgo biloba leaves powder (GBLP) by 1, 2 and 4% levels of diet, respectively. Group 5: positive control, was injected with Cis (7mg/kg body weight) to cause nephrotoxicity in rats. Groups 6, 7 and 8 were treated with GBLP by 1, 2 and 4% levels of diet, respectively and injected with Cis. At the end of the experimental period (6 weeks). The concentration of aspartate aminotransferase (AST), alanine aminotransferase (ALT), serum urea, creatinine levels, serum total proteins, albumin, malondialdehyde (MDA) and glutathione (GSH) were determined. Treatment with GBLP prior to Cis produced protective effects and attenuated these biochemical changes. The protective effects of GBLP were more pronounced for the high level. These results were confirmed by histopathologic observations of the kidney tissues. In conclusion, the beneficial effects of GBLP might be ascribable to its anti-inflammatory and antioxidant properties.
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