Assessment of the Pattern of Alternation of Glucose Homeostasis in Adult Patients with Beta Thalassemia

Abstract

Glucose homeostasis is the process of maintaining of blood glucose at steady-state. One significant disease that can affect glucose homeostasis is thalassemia. Iron over load in thalassemic patients affects insulin resistance and aggravates glucose disturbances leading to glucose intolerance and DM. Methods: This study was carried on 50 Patients with beta thalassemia, Also 20 healthy volunteers were enrolled as a control group to assess the pattern of alternation of glucose heamostasis in adult patients of beta thalasse mia. Results: Insulinogenic index was significaly reduced in thalassemic patients, whole body insulin sensetivity index was significaly reduced in thalassemic patients and Roc curve analysis of the studied parameters to assess glucose homeostasis revealed that, IG I had the highest sensitivity and specificity among the studied parameters. Conclusion: The incidence of diabetes mellities in 50 patients of thalassemia major was (10%), only 5 patients are diabetic, ferretin level was higher in thalassemic patient, so it could to attribute the pathogenesis of impairment of β-cell function, level of oral glucose tolerance test (0 minute) was higher in β-thalassemia major patients, two hour post prandial glucose was higher in thalassemic patients, whole body insulin sensetivity index was significaly reduced in thalassemic patients, insulinogenic index was significaly reduced in thalassemic patients and Roc curve analysis of the studied parameters to assess glucose homeostasis revealed that, IG I had the highest sensitivity and specificity among the studied
parameters.